United States securities and exchange commission logo February 16, 2023 James Hippel Chief Financial Officer Bio-Techne Corporation 614 McKinley Place N.E. Minneapolis, MN 55413 Re: Bio-Techne Corporation Form 10-K for the Fiscal Year Ended June 30, 2022 Filed August 24, 2022 File Number 000-17272 Dear James Hippel: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Life Sciences